The purpose of this study was to compare the session ratings of perceived exertion (Session-RPE) responses and the salivary cortisol (sC) and immunoglobulin A (SIgA) levels between a regular season match (RM) and the final championship match (FM) in elite male volleyball players against the same opponent team. Higher importance was assumed for FM as this match would define the championship team. Session-RPE was obtained after 30 min of each match using CR-10 scale. Saliva samples were collected before and after each match as well as during a rest day (baseline) at the same period of the matches. SIgA and sC concentrations were measured by ELISA. Greater Session-RPE was observed for FM as compared with RM (p < 0.01). The ANOVA showed greater sC concentrations to FM as compared to RM for both pre- and post-values as well as compared to baseline (p < 0.05). Significant lower SIgA pre-values were noted for FM. In conclusion, the results showed that match intensity, cortisol concentration and SIgA pre-level were affected by the match importance. These results indicate that monitoring session-RPE, sC and SIgA responses, in conjunction, during training and competition, would provide valuable informations regarding how athletes cope with sports induced stress. The present study provided knowledge about the effect of match importance on salivary markers related to stress that may help coaches to avoid excessive training loads reducing the likelihood to decrements on mucosal immunity and its consequently risk to upper respiratory tract infections, which in turn might affect the performance.